A lean bioabsorbable magnesium-zinc-calcium alloy ZX00 used for operative treatment of medial malleolus fractures early clinical results of a prospective non-randomized first in man study

Holweg, P., Herber V., Ornig, M., Hohenberger, G., Donohue, N., Puchwein, P., Leithner, A. and Seibert, F.

Bone & Joint Research, 2020, 9(8), pp.477-483.

This study is a prospective, non-randomized trial for the treatment of fractures of the medial malleolus using lean, bioabsorbable, rare-earth element (REE)-free, magnesium (Mg)-based biodegradable screws in the adult skeleton. This first prospective clinical investigation of fracture reduction and fixation using lean, bioabsorbable, REE-free ZX00 screws showed excellent clinical and functional outcomes.

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High-Strength Low-Alloy (HSLA) Mg-Zn-Ca Alloys with Excellent Biodegradation Performance

Hofstetter, J., Becker, M., Martinelli, E., Weinberg, A.-M., Mingler, B., Kilian, H., Pogatscher, S., Uggowitzer, P.J. and Loffler, J.F. .

The Journal of The Minerals, Metals & Materials Society (TMS), 2014; 66(4): p. 566-572

This article deals with the development of fine-grained high-strength low-alloy (HSLA) magnesium alloys intended for use as biodegradable implant material. The alloys contain solely low amounts of Zn and Ca as alloying elements.

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Assessing the degradation performance of ultrahigh-purity magnesium in vitro and in vivo

Hofstetter, J., Martinelli, E., Weinberg, A.-M., Becker, M. Mingler, B., Uggowitzer, P.J. and Loffler, J.F.

Corrosion Science, 2015, 91, pp.29-36.

The biodegradation of ultrahigh-purity Mg was tested in vitro in NaHCO3/CO2-buffered simulated body fluid and in vivo in the femur of rats. The less pure specimens exhibit significantly higher degradation rates due to the formation of Fe-containing precipitates during casting and annealing.

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A lean magnesium–zinc–calcium alloy ZX00 used for bone fracture stabilization in a large growing-animal model

Holweg, P., Berger, L., Cihova, M., Donohue, N., Clement, B., Schwarze, U., Sommer, N.G., Hohenberger, G., van den Beucken, J.J.J.P., Seibert, F., Leithner, A., Löffler, J.F., Weinberg, A.-M.

Acta Biomaterialia, Volume 113, 1 September 2020, Pages 646-659.


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MRI evaluation of resorbable poly lactic-co-glycolic acid (PLGA) screws used in pelvic osteotomies in children - a retrospective case series

H. Hedelin, H. Hebelka, H. Brisby & T. Laine

Journal of Orthopaedic Surgery and Research, 15, Article number: 329 (2020)

The orthopaedic use of resorbable poly lactic-co-glycolic acid (PLGA) implants carries multiple potential benefits. The aim of this study is to present an MRI-based evaluation of the resorption pattern and local tissue reactions in a paediatric case series after pelvic osteotomies fixated with PLGA screws. PLGA screws in the paediatric pelvis appear to be resorbed and replaced with solid bone in most cases but this process takes at least 2 years.


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Bioabsorbable Implants in Treatment of Ankle Fractures (Comparative Study)

V.G. Golubev, K.B. Zelenyak and A.N. Starostenkov
Department of Traumatology and Orthopedics, 2018 2(32), pp.66-73. In Russian.
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Patellar chondral defect treatment with a cell-free polyglycolic acid–hyaluronan-based implant and platelet-rich fibrin glue after previously failed microfracture

I. D. McDermott

SAGE Open Medical Case Reports, Volume 7: 1-4, 2019

Use of Bioretec ActivaNail™ with resorbable PGA–hyaluronan-based implant and platelet-rich autologous fibrin glue.

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Bony Fragment Excision Followed by Multiple Drilling and Fragment Fixation Using Bio-absorbable Pins for Bilateral Osteochondral Fracture of the Lateral Talar Dome: A Case Report

Y.J. Lee, J.S. Suh and J.Y. Choi

Journla of Korean Foot and Ankle Society, 2019 Dec; 23(4):201-207

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Clinical Study on Percutaneous Intramedullary Bioresorbable Pin Fixation for Fourth and Fifth Metacarpal Bone Fracture

S.H. Lee, S.H. Kim, E.S. Parl, S.M. Nam and H.S. Shin

Journal of the Korean Society for Surgery of the Hand, 2017;22(2):105-111

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Our First Experience of Using Biodegradable Implants in Latarjet – Bristow Surgical Procedure at Chronic Posttraumatic Anterior Shoulder Instability

V.V. Monastryev, M.E. Puseva and N.S. Ponomarenko

Acta Biomedica Scientifica, 2018, Vol. 3, N 6

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Minimally invasive surgery for young female patients with mild-to -moderate juvenile hallux valgus deformity

J. Y. Choi, H. C. Ahn, S. H. Kim, S. Y. Lee and J. S. Suh

Foot and Ankle Surgery 25 (2019) 316–322

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Correct techniques for the use of bioabsorbable implants in orthopaedic trauma

Zamora, R., Jackson, A. and Seligson D.

Current Orthopaedic Practice, vol 27, 4, July/Aug 2016

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Biodegradable poly-L-lactide-co-glycolide copolymer pin fixation of a traumatic patellar osteochondral fragment in a 11-year-old child: A novel surgical approach

J.-J. Sinikumpu and W. Serlo

Experimental and Therapeutic Medicine 13: 242-246, 2017

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Innominate Salter osteotomy using resorbable screws: a retrospective case series and presentation of a new concept for fixation

H. Hedelin, P. Larnert, H. Hebelka, H. Brisby, K. Lagerstrand, T. Laine.

Journal of Children's Orthopaedics Vol. 13, No. 3., 2019

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Latarjet-Bristow Procedure Performed With Bioabsorbable Screws - Computed Tomography Evidence of Healing

Allan Andrew Young, MD, MBBS, MSpMed, PhD, FRACS (Orth), Roberto Maia, MD, Claudio Moraga, MD, Vaqar Latif, MD, Jean-Pierre Liotard, MD, and Gilles Walch, MD

Techniques in Shoulder & Elbow Surgery, vol 11, 3, Sep. 2010

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A New Mini-Invasive Technique in Treating Pediatric Diaphyseal Forearm Fractures by Bioabsorbable Elastic Stable Intramedullary Nailing: A Preliminary Technical Report

J.-J. Sinikumpu, J. Keränen, A.-M. Haltia, W. Serlo, J. Merikanto

Scandinavian Journal of Surgery, Vol 102, Issue 4, 2013

We developed a new, two-stage mini-invasive surgical technique to stabilize the unstable diaphyseal fractures in children. The procedure is bioabsorbable elastic stable intramedullary nailing. Ultra-high-strength bioabsorbable intramedullary nails of poly(lactide-co-glycolide) were manufactured for our purpose. The material has been widely proven to be biocompatible and stable enough for fracture treatment as screws and pins. We have used the new technique in the unstable both-bone diaphyseal forearm fractures in children between the ages of 5 and 15 years. We report the technique and our clinical experience in the series of those three cases that have been followed up for at least 12 months. We report our preliminary experience of a new surgical mini-invasive procedure to stabilize the unstable pediatric forearm shaft fractures by bioabsorbable elastic stable intramedullary nailing. Our clinical experience suggests that the procedure combined with long-arm casting is feasible in treating the pediatric forearm fractures. The technique may bring benefits to handling these challenging fractures. The disadvantages of metallic implants may be avoided. In addition, removal of the implant will not be required.

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Operative Technique Features in Application Of Bioabsorbable Implants for Limb Fractures Treatment

V.G. Golubev, A.N. Starrostenkov

Surgeon Practice, No 2 / 2017; 617-089.844; 617.57; 617.58 Study translation from Russia to English.

Bioabsorbable screws and rods (pins) were used for the treatment of different types and locations of limb fractures in the Federal State-Funded Health Institution: Central Clinical Hospital of the Russian Academy of Sciences, Moscow in the orthopaedic trauma department between 2014 and 2016 for 120 patients. Interfragmentary fixation with bioabsorbable implants was applied as a single fixation method for 53 patients (44%), and in 67 (56%) cases it was combined with metallic plates and screws. Bioabsorbable implants were recognized as effective devices for interfragmentary fixation. Generally, bioabsorbable screws and rods (pins) did not require particular skills for the surgeon`s team and were in accordance with AO principles of fracture management.

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Absorbable Fixation in Forefoot Surgery A Viable Alternative to Metallic Hardware

D. L. Nielson, N. J. Young and C. M. Zelen

Clinics in Podiatric Medicine and Surgery, Volume 30, Issue 3, July 2013, Pages 283-293


  • Absorbable fixation has progressed to become a reliable, cost-effective alternative tometallic hardware.
  • Newer absorbable devices have been formulated to provide adequate strength for healingand a smooth degradation to limit the local inflammation typically associated with first-generation devices.
  • Historically, fixation with absorbable devices can be time-consuming due to a more diffi-cult insertion; however, new innovative technologies to aid in the insertion of these devicesare now becoming more common in the orthopedic realm.
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